Anti-alpha 2 Macroglobulin Antikörper [A2M/3622] (A277584)

Anti-alpha 2 Macroglobulin Antibody [A2M/3622]

Mouse monoclonal [A2M/3622] antibody to alpha 2 Macroglobulin.

α-2-Macroglobulin (α-2M) is a homotetrameric serum protein consisting of four identical subunits that form dimers through disulfide bonds. Initially, α-2M was characterized as a pan-proteinase inhibitor that was able to bait proteinases into cleaving specific peptide sequences on α-2M. This interaction induces a conformational change in α-2M, thus enabling it to trap the proteinase and further inhibit its activity. Subsequently, α-2M has been shown to function as a carrier protein and regulator of cytokines during inflammation. Circulating transforming growth factor β (TGFβ) in serum is primarily bound to α-2M, which renders TGFβ inactive. α-2M also binds to IL-6 and, thereby, increases the concentration of IL-6 near lymphocytes, hepatocytes and stem cells involved in mediating the inflammatory cascade. Mutations and deletions in the gene encoding α-2M are associated with an increased incidence of Alzheimer s disease (AD), which is consistent with the role of α-2M in mediating the clearance and degradation of A β, the major component of β-Amyloid deposits accumulated during AD.

IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 604-748, of human alpha 2 Macroglobulin. The exact sequence is proprietary.

Mouse

Monoclonal

A2M/3622

IgG2b

Unconjugated

Protein A/G chromatography.

200 µg/ml

185 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-alpha 2 Macroglobulin Antibody [A2M/3622] - BSA and Azide free (A278172).

A2m, A2MG_HUMAN, Alpha 2 M, Alpha 2M, Alpha-2-M, Alpha-2-macroglobulin, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, CPAMD5, DKFZp779B086, FWP007, S863 7