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Anti-CD40L Antikörper [2A3] (A279176)

$480

Monoklonal [2A3] Maus Antikörper gegen CD40L für WB und ELISA.

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-CD40L Antibody [2A3]
Beschreibung
Mouse monoclonal [2A3] antibody to CD40L.
Spezifität
This antibody recognises the soluble form of CD154, otherwise known as CD40 Ligand/TRAP, a ~32 kDa glycoprotein and member of the TNF family, which is specifically expressed on activated, but not resting, CD4+ T cells, dendritic cells (DCs), B cells and macrophages. CD154 binds CD40, and acts as a key co-stimulatory molecule through the activation of antigen-presenting cells, and as a regulator of the generation and functional properties of Th1 helper cells. CD154 exists in both a membrane-bound and soluble form, the latter of which is generated through proteolytic processing by a matrix metalloproteinase (MMP), in activated cells.The binding of CD154 with its receptor CD40 is vital for many biological processes, including Ig class switching, germinal centre formation and the survival of CD40+ B cells, B cell proliferation in the absence of co-stimulus, the production of IgE in the presence of interleukin-4 (IL-4), and also in the production of pro-inflammatory cytokines, MMPs, prostaglandins and adhesion molecule upregulation, in non-immune cells. recognises the soluble form of the protein.
Anwendungen
WB, ELISA
Reaktivität
Human
Immunogen
Recombinant human soluble CD154 conjugated to Bovine Serum Albumin.
Wirt
Mouse
Klonalität
Monoclonal
Klon
2A3
Isotyp
IgG1
Konjugat

Unconjugated

Reinigung
Protein A affinity chromatography of tissue culture supernatant.
Konzentration
1 mg/ml
Produktform
Liquid
Formulierung
Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.
Lagerung
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
Allgemeine Hinweise
Mouse anti Human CD154 (Soluble) antibody, clone 2A3 recognizes the soluble form of CD154, otherwise known as CD40 Ligand/TRAP, a ~32 kDa glycoprotein and member of the TNF family, which is specifically expressed on activated, but not resting, CD4+ T cells, dendritic cells (DCs), B cells and macrophages. CD154 binds CD40, and acts as a key co-stimulatory molecule through the activation of antigen-presenting cells, and as a regulator of the generation and functional properties of Th1 helper cells. CD154 exists in both a membrane-bound and soluble form, the latter of which is generated through proteolytic processing by a matrix metalloproteinase (MMP), in activated cells.The binding of CD154 with its receptor CD40 is vital for many biological processes, including Ig class switching, germinal centre formation and the survival of CD40+ B cells, B cell proliferation in the absence of co-stimulus, the production of IgE in the presence of interleukin-4 (IL-4), and also in the production of pro-inflammatory cytokines, MMPs, prostaglandins and adhesion molecule upregulation, in non-immune cells. Mouse anti Human CD154 (Soluble) antibody, clone 2A3 recognizes the soluble form of the protein.
Synonyme
CD 40L, CD154, CD40 antigen ligand, CD40 ligand, CD40 ligand, soluble form, CD40-L, CD40LG, CD40L_HUMAN, gp39, hCD40L, HIGM1, IGM, IMD3, soluble form, T B cell activating molecule, T BAM, T cell antigen Gp39 , T-cell antigen Gp39, TNF related activation protein, TNF-related activation protein, TNFSF5, TrAP, Tumor necrosis factor (ligand) superfamily member 5, Tumor necrosis factor (ligand) superfamily, member 5 (hyper-IgM syndrome), Tumor necrosis factor ligand superfamily member 5
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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