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Anti-Clostridium difficile Toxin A Antikörper [253/422] (A254034)

Monoklonal [253/422] Maus Antikörper gegen Clostridium difficile Toxin A für ELISA und IF.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-Clostridium difficile Toxin A Antibody [253/422] - BSA and Azide free
Beschreibung
Mouse monoclonal [253/422] antibody to Clostridium difficile Toxin A.
Spezifität
This antibody reacts with C. difficile Toxin A, but not with Cholera subunit a, Cholera toxin, Pseudomonas aeruginosa exotoxin A, H-LT, P-LT. Clostridium difficile is a major nosocomial pathogen that causes antibiotic- associated colitis. Clostridium difficile mediates inflammatory diarrhea by releasing two large protein enterotoxins (Toxin A and Toxin B) that are able to disrupt intestinal epithelial cells via their transferase activity and ability to monoglucosylate members of the Rho family. Clostridium difficile Toxin A is a toxin that is composed of 39 repeats that are responsible for binding to intestinal epithelial cell surface carbohydrates. Clostridium difficile Toxin A causes significant apoptosis of colonocytes which contributes to the formation of ulcers and pseudo-membranes in a pathway that involves p38-dependent activation of p53 and induction of p21, leading to cytochrome c release and caspase-3 activation through Bak activation.
Anwendungen
ELISA, IF
Verdünnungen
ELISA: 1-5 µg/ml, IF: 1-2 µg/ml
Reaktivität
Clostridium difficile
Immunogen
C. difficile Toxin A.
Wirt
Mouse
Klonalität
Monoclonal
Klon
253/422
Isotyp
IgG1
Leichte Ketten
kappa
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
1 mg/ml
Molekulargewicht
308 kDa (Toxin A)
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Allgemeine Hinweise
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Clostridium difficile Toxin A Antibody [253/422] (A250854).
Synonyme
tcdA, toxA
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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