Anti-CPS1 Antikörper [CPS1/8417] (A314812)

Anti-CPS1 Antibody [CPS1/8417]

Mouse monoclonal [CPS1/8417] antibody to CPS1.

This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

IHC-P

HeLa cells. Liver or Hepatocellular Carcinoma (HCC).

IHC: 1-2 µg/ml

Human

Recombinant human CPS1 protein.

Mouse

Monoclonal

CPS1/8417

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

~165 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Carbamoyl phosphate synthase, Carbamoyl phosphate synthase [ammonia], Carbamoyl phosphate synthase [ammonia] mitochondrial, Carbamoyl phosphate synthetase 1, Carbamoyl phosphate synthetase 1 mitochondrial, Carbamoyl phosphate synthetase I, Carbamoyl-phosphate synthase [ammonia], Carbamoyl-phosphate synthetase I, Carbamoylphosphate synthase, Carbamoylphosphate synthetase 1, Carbamoylphosphate synthetase I, CPS 1, CPSase 1, CPSase I, CPSASE1, CPSM_HUMAN, mitochondrial, MS738