Anti-Fas Antikörper [FAS/3112] (A249020)

Name: Anti-Fas Antibody [FAS/3112]
Brand: Antibodies.com
SKU: A249020
Price: 525.0 USD
Availability: InStock

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$525

Monoklonal [FAS/3112] Maus Antikörper gegen Fas für ELISA und IHC-P.

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Alternative Formats and ConjugatesAlternative Formats

Carrier Free and Preservative Free

Versand

Versandkosten

$40

Vorlaufzeit

Lieferung in 4-6 Werktagen

Kontakt

Telefon

+1 (314) 370-6046

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Stichworte:

Monospezifischer Antikörper Plasma Membrane Marker

Produktdetails

Produktname

Anti-Fas Antibody [FAS/3112]

Beschreibung

Mouse monoclonal [FAS/3112] antibody to Fas.

Spezifität

This antibody specifically recognizes CD95, also known as Fas, a transmembrane glycoprotein with a MW of 40-45kDa, containing 8kDa of N-glycoside-linked polysaccharide. It is a receptor for TNFSF6/FASLG, a member of the nerve growth factor receptor/tumor necrosis factor superfamily, mediating receptor-triggered apoptosis. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation, which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). CD95 antigen is expressed on the surface of various cell types, preferentially on the CD45RAlow CD45ROhigh subset of memory T lymphocytes.

Anwendungen

ELISA, IHC-P

Verdünnungen

IHC-P: 1-2 µg/ml

Reaktivität

Human

Immunogen

Recombinant fragment, around amino acids 26-96, of human CD95 protein. The exact sequence is proprietary.

Wirt

Mouse

Klonalität

Monoclonal

Klon

FAS/3112

Isotyp

IgG2b

Leichte Ketten

kappa

Konjugat

Unconjugated

Reinigung

Protein A/G chromatography.

Konzentration

200 µg/ml

Molekulargewicht

38-50 kDa

Produktform

Liquid

Formulierung

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Lagerung

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Allgemeine Hinweise

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-Fas Antibody [FAS/3112] - BSA and Azide free (A252200).

Synonyme

ALPS 1A, ALPS1A, APO 1, Apo 1 antigen, APO 1 cell surface antigen, Apo-1 antigen, APO1, Apo1 antigen, APO1 cell surface antigen, Apoptosis antigen 1, Apoptosis mediating surface antigen FAS, Apoptosis-mediating surface antigen FAS, APT 1, APT1, CD 95, CD 95 antigen, CD95, CD95 antigen , Delta Fas, Delta Fas/APO 1/CD95, Delta Fas/APO1/CD95, Fas (TNF receptor superfamily, member 6), FAS 1, FAS 827dupA, Fas AMA, FAS Antigen, Fas cell surface death receptor, FAS1, FASLG receptor, FASTM, sFAS, Surface antigen APO1, TNF receptor superfamily, member 6, TNFRSF 6, TNFRSF6, TNR6_HUMAN, Tumor necrosis factor receptor superfamily member 6

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

Produktbilder (4)

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Figure 1: Immunohistochemistry - Anti-Fas Antibody [FAS/3112] (A249020)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon using Anti-Fas Antibody [FAS/3112].

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Figure 2: Immunohistochemistry - Anti-Fas Antibody [FAS/3112] (A249020)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon using Anti-Fas Antibody [FAS/3112].

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Figure 3: SDS-PAGE - Anti-Fas Antibody [FAS/3112] (A249020)

SDS-PAGE analysis of Anti-Fas Antibody [FAS/3112] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.

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Figure 4: Anti-Fas Antibody [FAS/3112] (A249020)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-Fas Antibody [FAS/3112]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.