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Anti-FLI1 Antikörper [FLI1/7508] (A316355)

$765

Monoklonal [FLI1/7508] Maus Antikörper gegen FLI1 für WB und IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-FLI1 Antibody [FLI1/7508] - BSA and Azide free
Beschreibung
Mouse monoclonal [FLI1/7508] antibody to FLI1.
Spezifität
Recognizes a protein of 51kDa, which is identified as FLI1. This protein, a member of the ETS family of DNA binding transcription factors, is involved in cellular proliferation and tumorigenesis. Ets-1 is the prototype member of a family of genes identified on the basis of homology to the v-Ets oncogene isolated from the E26 erythroblastosis virus. Members of the Ets gene family share a highly conserved carboxy-terminal domain containing a sequence related to the SV40 large T antigen nuclear localization signal sequence. Approximately 90% of Ewing s Sarcoma (EWS) / Primitive Neuroectodermal Tumors (PNET) have a specific translocation, t(11;22)(q24;q12), which results in fusion of EWS to Fli-1, and production of an EWS-Fli-1 fusion protein. Among normal tissues only endothelial cells and small lymphocytes express Fli-1. This protein is expressed in majority of vascular tumors including angiosarcomas, hemangioendotheliomas, hemangiomas, and Kaposi s Sarcomas. High sensitivity and specificity of Fli-1 equals to or exceeds that of the established vascular markers like CD31, CD34, and Factor VIII.
Anwendungen
WB, IHC-P
Positivkontrolle
THP1 and Raji cells. Tonsil, Ewing s sarcoma (EWS) and Angiosarcoma
Verdünnungen
WB: 1-2 µg/ml, IHC: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant fragment (aa 107-261) of human FLI1 protein with hexa-histidine tag.
Wirt
Mouse
Klonalität
Monoclonal
Klon
FLI1/7508
Isotyp
IgG2
Leichte Ketten
kappa
Konjugat

Unconjugated

Reinigung
Protein A chromatography.
Konzentration
1 mg/ml
Molekulargewicht
51 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyme
ERGB transcription factor, Ewing Sarcoma breakpoint region 2, EWSR 2, EWSR2, FLI 1, FLI 1 proto oncogene, Fli-1 proto-oncogene, ETS transcription factor, FLI1 EWS fusion gene, FLI1 proto oncogene, FLI1_HUMAN, Friend leukemia integration 1 (FLI1) transcription factor, Friend leukemia integration 1 transcription factor, Friend leukemia virus integration 1, Proto-oncogene Fli-1, Sarcoma breakpoint region 2 (EWSR2), SIC 1, SIC1, Transcription factor ERGB, Viral integration region FLI1, Viral integration region FLI1, mouse, homolog of
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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