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Anti-GRAMD4 Antikörper [PCRP-GRAMD4-1A10] (A277610)

Monoklonal [PCRP-GRAMD4-1A10] Maus Antikörper gegen GRAMD4 für Flow Cytometry und IF.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-GRAMD4 Antibody [PCRP-GRAMD4-1A10]
Beschreibung
Mouse monoclonal [PCRP-GRAMD4-1A10] antibody to GRAMD4.
Spezifität
The gene encoding GRAMD4 (GRAM domain-containing protein 4) maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. GRAMD4, also designated death-inducing protein (DIP), is a 578 amino acid mitochondrial membrane protein that acts as an essential mediator of the p53-independent E2F-1 death pathway, which is frequently found to be deregulated in several types of cancers. Overexpression of GRAMD4 results in a strong apoptotic response involving caspase-3 activation and cleavage of poly(ADP-ribose)-polymerase. GRAMD4 is expressed in lung and in primary lung squamous cell carcinoma (LSCC) and shows upregulation in mitochondria by E2F1 after addition of 4-hydroxytamoxifen. This evidence suggests that GRAMD4 may be a potential target for cancer therapies.
Anwendungen
Flow Cytometry, IF
Verdünnungen
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml
Reaktivität
Human
Kreuzreaktivität
This antibody is predicted to cross react with Rat.
Immunogen
Recombinant full-length human GRAMD4 protein.
Wirt
Mouse
Klonalität
Monoclonal
Klon
PCRP-GRAMD4-1A10
Isotyp
IgG1
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
66 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Allgemeine Hinweise
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-GRAMD4 Antibody [PCRP-GRAMD4-1A10] - BSA and Azide free (A278198).
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.
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