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Anti-ID1 Antikörper [PCRP-ID1-2F11] (A277652)

Monoklonal [PCRP-ID1-2F11] Maus Antikörper gegen ID1 für ELISA, IP, Flow Cytometry und IF.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-ID1 Antibody [PCRP-ID1-2F11]
Beschreibung
Mouse monoclonal [PCRP-ID1-2F11] antibody to ID1.
Spezifität
Members of the Id family of basic helix-loop-helix (bHLH) proteins include Id1, Id2, Id3 and Id4. They are ubiquitously expressed and dimerize with members of the class A and B HLH proteins. Due to the absence of the basic region, the resulting heterodimers cannot bind DNA. The Id-type proteins thus appear to negatively regulate DNA binding of bHLH proteins. Since Id1 inhibits DNA binding of E12 and Myo D, it apparently functions to inhibit muscle-specific gene expression. Under conditions that facilitate muscle cell differentiation, the Id protein levels fall, allowing E12 and/or E47 to form heterodimers with Myo D and myogenin, which in turn activate myogenic differentiation. It has been shown that expression of each of the Id proteins is strongly dependent on growth factor activation and that reduction of Id mRNA levels by antisense oligonucleotides leads to a delayed reentry of arrested cells into the cell cycle following growth factor stimulation.
Anwendungen
ELISA, IP, Flow Cytometry, IF
Verdünnungen
IP: 1-2µg / 100-500µg proteins, Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml
Reaktivität
Human
Immunogen
Recombinant fragment, around amino acids 5-150, of human ID1 protein. The exact sequence is proprietary.
Wirt
Mouse
Klonalität
Monoclonal
Klon
PCRP-ID1-2F11
Isotyp
IgG1
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
16.13 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Allgemeine Hinweise
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-ID1 Antibody [PCRP-ID1-2F11] - BSA and Azide free (A278240).
Synonyme
bHLHb24, Class B basic helix-loop-helix protein 24, dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein), DNA binding protein inhibitor ID 1, DNA binding protein inhibitor ID1, DNA-binding protein inhibitor ID-1, Dominant negative helix loop helix protein, ID, ID 1, ID1_HUMAN, Inhibitor of Differentiation 1, Inhibitor of DNA binding 1, inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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