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Anti-MED7 Antikörper [PCRP-MED7-1B8] (A277851)

Monoklonal [PCRP-MED7-1B8] Maus Antikörper gegen MED7 für ELISA, Flow Cytometry, IF und IP.

Alternative Formats and ConjugatesAlternative Formats

Versandkosten
Vorlaufzeit
Lieferung in 4-6 Werktagen
Telefon
+1 (314) 370-6046
Mo bis Frei, 8am - 4pm AST
Email
orders@antibodies.com
Produktname
Anti-MED7 Antibody [PCRP-MED7-1B8]
Beschreibung
Mouse monoclonal [PCRP-MED7-1B8] antibody to MED7.
Spezifität
MED7, also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, MED7 functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5'-NACUAAY-N(1,20)-UAAY-3'. Additionally, MED7 regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. MED7 may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases MED7 mRNA-binding affinity. Defects or deletions in the gene encoding MED7 are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of MED7 exist due to alternative splicing events.
Anwendungen
ELISA, Flow Cytometry, IF, IP
Verdünnungen
Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml, IP: 1-2µg / 100-500µg proteins
Reaktivität
Human
Immunogen
Recombinant full-length human MED7 protein.
Wirt
Mouse
Klonalität
Monoclonal
Klon
PCRP-MED7-1B8
Isotyp
IgG2b
Konjugat

Unconjugated

Reinigung
Protein A/G chromatography.
Konzentration
200 µg/ml
Molekulargewicht
27.2 kDa
Produktform
Liquid
Formulierung
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Lagerung
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Allgemeine Hinweise
This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MED7 Antibody [PCRP-MED7-1B8] - BSA and Azide free (A278439).
Synonyme
Activator recruited cofactor 34 kDa component, Activator-recruited cofactor 34 kDa component, ARC34, Cofactor required for Sp1 transcriptional activation subunit 9, Cofactor required for Sp1 transcriptional activation, subunit 9 (33kD), Cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa, CRSP complex subunit 9, CRSP33, CRSP9, hMED7, MED7_HUMAN, Mediator complex subunit 7, Mediator of RNA polymerase II transcription subunit 7, MGC12284, RNA polymerase transcriptional regulation mediator subunit 7 homolog, Transcriptional coactivator CRSP33
Haftungsausschluss
Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

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