Anti-MerTK Antikörper [MERTK/3023] (A277530)

Name: Anti-MerTK Antibody [MERTK/3023]
Brand: Antibodies.com
SKU: A277530
Price: 525.0 USD
Availability: InStock

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$525

Monoklonal [MERTK/3023] Maus Antikörper gegen MerTK für IHC-P.

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Carrier Free and Preservative Free

Versand

Versandkosten

$40

Vorlaufzeit

Lieferung in 4-6 Werktagen

Kontakt

Telefon

+1 (314) 370-6046

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Stichworte:

Monospezifischer Antikörper

Produktdetails

Produktname

Anti-MerTK Antibody [MERTK/3023]

Beschreibung

Mouse monoclonal [MERTK/3023] antibody to MerTK.

Spezifität

MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C Î³2 (PI-PLC Î³2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.

Anwendungen

IHC-P

Verdünnungen

IHC-P: 1-2 µg/ml

Reaktivität

Human

Immunogen

Recombinant fragment, around amino acids 5-148, of human MerTK. The exact sequence is proprietary.

Wirt

Mouse

Klonalität

Monoclonal

Klon

MERTK/3023

Isotyp

IgG2a

Konjugat

Unconjugated

Reinigung

Protein A/G chromatography.

Konzentration

200 µg/ml

Molekulargewicht

110 kDa

Produktform

Liquid

Formulierung

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Lagerung

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Allgemeine Hinweise

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MerTK Antibody [MERTK/3023] - BSA and Azide free (A278118).

Synonyme

c MER, c mer proto oncogene tyrosine kinase, c-mer, cMER, cmer protooncogene tyrosine kinase, Eyk, MER, MER receptor tyrosine kinase, MERK, MERPEN, MERTK c-mer proto-oncogene tyrosine kinase, MERTK_HUMAN, MGC133349, nmf12, Nyk, Proto oncogene tyrosine protein kinase MER, Proto oncogene tyrosine protein kinase MER precursor, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, RP38, STK kinase, Tyrosine-protein kinase Mer

Isotyp-Kontrollantikörper

Kompatible Sekundärantikörper

Haftungsausschluss

Dieses Produkt ist nur für Forschungszwecke bestimmt. Es ist nicht für diagnostische oder therapeutische Zwecke bestimmt.

Produktbilder (3)

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Figure 1: Immunohistochemistry - Anti-MerTK Antibody [MERTK/3023] (A277530)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma tissue using Anti-MerTK Antibody [MERTK/3023].

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Figure 2: Immunohistochemistry - Anti-MerTK Antibody [MERTK/3023] (A277530)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma tissue using Anti-MerTK Antibody [MERTK/3023].

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Figure 3: Anti-MerTK Antibody [MERTK/3023] (A277530)

Analysis of protein array containing more than 19,000 full-length human proteins using Anti-MerTK Antibody [MERTK/3023]. Z-Score and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt^TM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt^TM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target; a MAb is considered to be specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.