Rekombinant Anti-PAX6 Antikörper [PAX6/7078R] (A278627)

Anti-PAX6 Antibody [PAX6/7078R] - BSA and Azide free

Recombinant rabbit monoclonal [PAX6/7078R] antibody to PAX6.

Pax genes contain paired domains with strong homology to genes in Drosophila, which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.

Flow Cytometry, IF, WB

Flow Cytometry: 0.5-1 µg/million cells, IF: 0.5-1 µg/ml, WB: 1-2 µg/ml

Human

Recombinant fragment corresponding to the N terminus, around amino acids 1-300, of human PAX6 protein.

Rabbit

Monoclonal

PAX6/7078R

IgG

Unconjugated

Protein A/G chromatography.

1 mg/ml

47 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-PAX6 Antibody [PAX6/7078R] (A278039).

AN, AN 2, AN2, Aniridia type II protein, D11S812E, FVH1, KIAA0552, Leucine zipper putative tumor suppressor 3, LZTS3, MGC17209, MGDA, Oculorhombin, Paired box 6, Paired Box Gene 6, Paired box gene 6 (aniridia keratitis), Paired box homeotic gene 6, Paired box protein Pax-6, Paired box protein Pax6, PAX 6, PAX6_HUMAN, ProSAP-interacting protein 1, PROSAPIP1, Sey, WAGR