Angiopoietin 2 ist ein Gen, das durch das Symbol ANGPT2 kodiert wird. Andere Namen sind: Angiopoietin-2; ANG-2; ANGPT2. Angiopoietin 2 hat eine Masse von 56.92kDa und eine Aminosäurelänge von 496.
Wir bieten 9 Angiopoietin 2 ELISA-Kits zum qualitativen oder quantitativen Nachweis von Angiopoietin 2 von Human, Maus, Ratte, Schwein und Kaninchen proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
Entrez Zusammenfassung
The protein encoded by this gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene.
