Apolipoprotein H ist ein Gen, das durch das Symbol APOH kodiert wird. Andere Namen sind: Beta-2-glycoprotein 1; APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apo-H; Beta-2-glycoprotein I; B2GPI; APOH; B2G1. Apolipoprotein H hat eine Masse von 38.3kDa und eine Aminosäurelänge von 345.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
Entrez Zusammenfassung
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections.
Gewebespezifität
Expressed by the liver and secreted in plasma.
Posttranslationale Modifikation
N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele.
