Calnexin ist ein Gen, das durch das Symbol CANX kodiert wird. Andere Namen sind: IP90; Major histocompatibility complex class I antigen-binding protein p88; p90; CANX. Calnexin hat eine Masse von 67.57kDa und eine Aminosäurelänge von 592.
Wir bieten 6 Calnexin ELISA-Kits zum qualitativen oder quantitativen Nachweis von Calnexin von Human, Maus und Ratte proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.
Entrez Zusammenfassung
This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described.
Sequenzähnlichkeiten
Belongs to the calreticulin family.
Posttranslationale Modifikation
Phosphorylated at Ser-564 by MAPK3/ERK1. phosphorylation by MAPK3/ERK1 increases its association with ribosomes (By similarity).
Zellort
Endoplasmic reticulum membrane. Endoplasmic reticulum. Melanosome.
Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545, PubMed:17081065). The palmitoylated form preferentially localizes to the perinuclear rough ER (PubMed:22314232).
