eIF4EBP1 ist ein Gen, das durch das Symbol EIF4EBP1 kodiert wird. Andere Namen sind: Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I. eIF4EBP1 hat eine Masse von 12.58kDa und eine Aminosäurelänge von 118.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Entrez Zusammenfassung
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
Sequenzähnlichkeiten
Belongs to the eIF4E-binding protein family.
Posttranslationale Modifikation
Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.
