ELK1 ist ein Gen, das durch das Symbol ELK1 kodiert wird. Es ist auch bekannt als ETS domain-containing protein Elk-1. ELK1 hat eine Masse von 44.89kDa und eine Aminosäurelänge von 428.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2. Induces target gene transcription upon JNK-signaling pathway stimulation (By similarity).
Entrez Zusammenfassung
This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14.
Gewebespezifität
Lung and testis.
Sequenzähnlichkeiten
Belongs to the ETS family.
Posttranslationale Modifikation
Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention.
