FLAP ist ein Gen, das durch das Symbol ALOX5AP kodiert wird. Andere Namen sind: Arachidonate 5-lipoxygenase-activating protein; MK-886-binding protein; ALOX5AP. FLAP hat eine Masse von 18.16kDa, eine Aminosäurelänge von 161, und ist an Ischemic stroke beteiligt.
Wir bieten 2 FLAP ELISA-Kits zum qualitativen oder quantitativen Nachweis von FLAP von Human und Ratte proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Entrez Zusammenfassung
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Rolle bei Krankheiten
Ischemic stroke: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
Sequenzähnlichkeiten
Belongs to the MAPEG family.
Zellort
Nucleus membrane. Endoplasmic reticulum membrane.
