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Granulin Assays

14 Products

Granulin ist ein Gen, das durch das Symbol GRN kodiert wird. Im Allgemeinen auch bezeichnet als: ProPGRN; Acrogranin; Epithelin precursor; Glycoprotein of 88 Kda; GP88 precursor; PC cell-derived growth factor; PCDGF; Proepithelin; PEPI; GRN. Granulin hat eine Masse von 63.54kDa, eine Aminosäurelänge von 593, und ist an folgenden Krankheiten beteiligt: Ubiquitin-positive frontotemporal dementia; Ceroid lipofuscinosis, neuronal, 11.

Wir bieten 14 Granulin ELISA-Kits zum qualitativen oder quantitativen Nachweis von Granulin von Human, Maus und Ratte proben.

Gen- und Proteininformationen

UniProt Zusammenfassung
Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:28541286, PubMed:28073925, PubMed:18378771, PubMed:28453791, PubMed:12526812). Regulates protein trafficking to lysosomes and, also the activity of lysosomal enzymes (PubMed:28453791, PubMed:28541286). Facilitates also the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (By similarity). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:12526812). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:18378771).
Entrez Zusammenfassung
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.
Gewebespezifität
In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.
Rolle bei Krankheiten
Ubiquitin-positive frontotemporal dementia: Frontotemporal dementia (FTD) is the second most common cause of dementia in people under the age of 65 years. It is an autosomal dominant neurodegenerative disease.

Ceroid lipofuscinosis, neuronal, 11: A form of neuronal ceroid lipofuscinosis characterized by rapidly progressive visual loss due to retinal dystrophy, seizures, cerebellar ataxia, and cerebellar atrophy. Cognitive decline may also occur. Neuronal ceroid lipofuscinoses are progressive neurodegenerative, lysosomal storage diseases characterized by intracellular accumulation of autofluorescent liposomal material.
Sequenzähnlichkeiten
Belongs to the granulin family.
Posttranslationale Modifikation
Cleaved by ELANE; proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production; granulin-3 and granulin-4 are resistant to ELANE (PubMed:12526812, PubMed:28743268). Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome (PubMed:28743268).
Zellort
Secreted. Lysosome.

Endocytosed by SORT1 and delivred to lysosomes (PubMed:21092856, PubMed:28073925). Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (PubMed:26370502, PubMed:28073925). Co-localized with GBA in the intracellular trafficking compartments until to lysosome (By similarity).
Standard Curve - Rat Granulin ELISA Kit (A80016) - Antibodies.com
Standard Curve - Human Progranulin ELISA Kit (A87391) - Antibodies.com
Standard Curve - Mouse Progranulin ELISA Kit (A78665) - Antibodies.com
Standard Curve - Human Granulin ELISA Kit (A79400) - Antibodies.com
Standard Curve - Rat Progranulin ELISA Kit (A80136) - Antibodies.com
Standard Curve - Human Granulin ELISA Kit (A312011) - Antibodies.com
Produkt anzeigen90-Minuten-ELISA
Standard Curve - Mouse Granulin ELISA Kit (A78204) - Antibodies.com
Standard Curve - Mouse Granulin ELISA Kit (A310348) - Antibodies.com
Produkt anzeigen90-Minuten-ELISA
Standard Curve - Mouse Granulin ELISA Kit (DL-GRN-Mu) - Antibodies.com
Standard Curve - Human Progranulin ELISA Kit (OK-0348) - Antibodies.com
(3)
Standard Curve - Human Progranulin ELISA Kit (Lum-8348) - Antibodies.com
(3)
Standard Curve - Human Granulin ELISA Kit (DL-GRN-Hu) - Antibodies.com
Standard Curve - Human Granulin ELISA Kit (EK1184) - Antibodies.com
Standard Curve - Rat Granulin ELISA Kit (DL-GRN-Ra) - Antibodies.com

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