IL18 ist ein Gen, das durch das Symbol IL18 kodiert wird. Im Allgemeinen auch bezeichnet als: Interleukin-18; IL-18; Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma; IL-1 gamma; IGIF; IL1F4. IL18 hat eine Masse von 22.33kDa und eine Aminosäurelänge von 193.
Wir bieten 25 IL18 ELISA-Kits zum qualitativen oder quantitativen Nachweis von IL18 von Human, Maus, Ratte, Rind, Schwein, Kaninchen, Huhn, Hund, Goat und Meerschweinchen proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (PubMed:14528293, PubMed:25500532). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable) (PubMed:10653850).
Entrez Zusammenfassung
The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Sequenzähnlichkeiten
Belongs to the IL-1 family.
Posttranslationale Modifikation
The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.
