Interleukin 34 ist ein Gen, das durch das Symbol IL34 kodiert wird. Im Allgemeinen auch bezeichnet als: Interleukin-34; IL-34; IL34; C16orf77. Interleukin 34 hat eine Masse von 27.48kDa und eine Aminosäurelänge von 242.
Wir bieten 10 Interleukin 34 ELISA-Kits zum qualitativen oder quantitativen Nachweis von Interleukin 34 von Human, Maus und Ratte proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
Entrez Zusammenfassung
Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008
Gewebespezifität
Detected in the sinusoidal epithelium in the red pulp of spleen (at protein level). Predominantly expressed in spleen. Also detected in a range of other tissues including heart, brain, lung, liver, kidney, thymus, testis, ovary, small intestine, prostate and colon.
Sequenzähnlichkeiten
Belongs to the IL-34 family.
