Mesothelin ist ein Gen, das durch das Symbol MSLN kodiert wird. Im Allgemeinen auch bezeichnet als: CAK1 antigen; Pre-pro-megakaryocyte-potentiating factor; MSLN; MPF. Mesothelin hat eine Masse von 68.99kDa und eine Aminosäurelänge von 630.
Wir bieten 6 Mesothelin ELISA-Kits zum qualitativen oder quantitativen Nachweis von Mesothelin von Human und Maus proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Membrane-anchored forms may play a role in cellular adhesion.
Entrez Zusammenfassung
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiating factor functions as a cytokine that can stimulate colony formation of bone marrow megakaryocytes. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Gewebespezifität
Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
Sequenzähnlichkeiten
Belongs to the mesothelin family.
Posttranslationale Modifikation
Both MPF and the cleaved form of mesothelin are N-glycosylated.
Zellort
Cell membrane. Golgi apparatus.
