Milk Fat Globule 1 ist ein Gen, das durch das Symbol MFGE8 kodiert wird. Im Allgemeinen auch bezeichnet als: Lactadherin; Breast epithelial antigen BA46; HMFG; MFGM; Milk fat globule-EGF factor 8; MFG-E8; SED1; MFGE8. Milk Fat Globule 1 hat eine Masse von 43.11kDa und eine Aminosäurelänge von 387.
Wir bieten 3 Milk Fat Globule 1 ELISA-Kits zum qualitativen oder quantitativen Nachweis von Milk Fat Globule 1 von Human und Maus proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.
Entrez Zusammenfassung
This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants.
Gewebespezifität
Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.
Posttranslationale Modifikation
Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.
Zellort
Membrane. Secreted.
