MMP8 ist ein Gen, das durch das Symbol MMP8 kodiert wird. Im Allgemeinen auch bezeichnet als: Neutrophil collagenase; Matrix metalloproteinase-8; MMP-8; PMNL collagenase; PMNL-CL; CLG1. MMP8 hat eine Masse von 53.41kDa und eine Aminosäurelänge von 467.
Wir bieten 10 MMP8 ELISA-Kits zum qualitativen oder quantitativen Nachweis von MMP8 von Human, Maus, Ratte und Meerschweinchen proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Can degrade fibrillar type I, II, and III collagens.
Entrez Zusammenfassung
This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
Gewebespezifität
Neutrophils.
Sequenzähnlichkeiten
Belongs to the peptidase M10A family.
Zellort
Cytoplasmic granule. Secreted > Extracellular space > Extracellular matrix.
Stored in intracellular granules.
