Pepsinogen II ist ein Gen, das durch das Symbol PGC kodiert wird. Im Allgemeinen auch bezeichnet als: Gastricsin; Pepsinogen C; PGC. Pepsinogen II hat eine Masse von 42.43kDa und eine Aminosäurelänge von 388.
Wir bieten 5 Pepsinogen II ELISA-Kits zum qualitativen oder quantitativen Nachweis von Pepsinogen II von Human, Maus, Ratte und Huhn proben.
Gen- und Proteininformationen
UniProt Zusammenfassung
Hydrolyzes a variety of proteins.
Entrez Zusammenfassung
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Sequenzähnlichkeiten
Belongs to the peptidase A1 family.
