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SDF1 alpha Assays

4 Products

SDF1 alpha ist ein Gen, das durch das Symbol CXCL12 kodiert wird. Es ist auch bekannt als: Stromal cell-derived factor 1; SDF-1; C-X-C motif chemokine 12; Intercrine reduced in hepatomas; IRH; Pre-B cell growth-stimulating factor; PBSF; CXCL12; SDF1; SDF1A; SDF1B. SDF1 alpha hat eine Masse von 10.67kDa und eine Aminosäurelänge von 93.

Wir bieten 4 SDF1 alpha ELISA-Kits zum qualitativen oder quantitativen Nachweis von SDF1 alpha von Human, Maus, Ratte und Schwein proben.

Gen- und Proteininformationen

UniProt Zusammenfassung
Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity).
Gewebespezifität
Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.
Sequenzähnlichkeiten
Belongs to the intercrine alpha (chemokine CxC) family.
Posttranslationale Modifikation
Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
Zellort
Secreted.
Datenbank-Links
Standard Curve - Mouse Stromal Cell Derived Factor 1 ELISA Kit (DL-SDF1-Mu) - Antibodies.com
Standard Curve - Human Stromal Cell Derived Factor 1 ELISA Kit (DL-SDF1-Hu) - Antibodies.com
Standard Curve - Porcine Stromal Cell Derived Factor 1 ELISA Kit (DL-SDF1-p) - Antibodies.com
Standard Curve - Rat Stromal Cell Derived Factor 1 ELISA Kit (DL-SDF1-Ra) - Antibodies.com

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