Syndecan-1 ist ein Gen, das durch das Symbol SDC1 kodiert wird. Es ist auch bekannt als: SYND1; SDC1; SDC. Syndecan-1 hat eine Masse von 32.46kDa und eine Aminosäurelänge von 310.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413).
Entrez Zusammenfassung
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
Sequenzähnlichkeiten
Belongs to the syndecan proteoglycan family.
Posttranslationale Modifikation
Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3.
Zellort
Membrane. Secreted. Secreted > Extracellular exosome.
Shedding of the ectodomain produces a soluble form.
