Tissue Factor Pathway Inhibitor ist ein Gen, das durch das Symbol TFPI kodiert wird. Es ist auch bekannt als: TFPI; Extrinsic pathway inhibitor; EPI; Lipoprotein-associated coagulation inhibitor; LACI; TFPI1. Tissue Factor Pathway Inhibitor hat eine Masse von 35.02kDa und eine Aminosäurelänge von 304.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma.
Entrez Zusammenfassung
This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization.
Gewebespezifität
Mostly in endothelial cells.
Posttranslationale Modifikation
O-glycosylated.
