ADK ist ein Gen, das durch das Symbol ADK kodiert wird. Andere Namen sind: Adenosine kinase; AK; Adenosine 5'-phosphotransferase. ADK hat eine Masse von 40.55kDa, eine Aminosäurelänge von 362, und ist an Hypermethioninemia due to adenosine kinase deficiency beteiligt.
Wir bieten 7 antikörper gegen ADK, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.
Entrez Zusammenfassung
This gene an enzyme which catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Multiple transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Widely expressed. Highest level in placenta, liver, muscle and kidney.
Rolle bei Krankheiten
Hypermethioninemia due to adenosine kinase deficiency: A metabolic disorder characterized by global developmental delay, early-onset seizures, mild dysmorphic features, and characteristic biochemical anomalies, including persistent hypermethioninemia with increased levels of S-adenosylmethionine and S-adenosylhomocysteine. Homocysteine levels are typically normal.
Sequenzähnlichkeiten
Belongs to the carbohydrate kinase PfkB family.
