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Anti-AIRE Antikörper

14 Products

AIRE ist ein Gen, das durch das Symbol AIRE kodiert wird. Andere Namen sind: Autoimmune regulator; Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein; APECED protein; APECED. AIRE hat eine Masse von 57.73kDa, eine Aminosäurelänge von 545, und ist an Autoimmune polyendocrine syndrome 1, with or without reversible metaphyseal dysplasia beteiligt.

Wir bieten 14 antikörper gegen AIRE, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus, Ratte und Schwein.

Gen- und Proteininformationen

UniProt Zusammenfassung
Transcription factor playing an essential role to promote self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery, called tissue restricted antigens (TRA) (PubMed:26084028). Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Mainly expressed by medullary thymic epithelial cells (mTECs), induces the expression of thousands of tissue-restricted proteins, which are presented on major histocompatibility complex class I (MHC-I) and MHC-II molecules to developing T-cells percolating through the thymic medulla (PubMed:26084028). Also induces self-tolerance through other mechanisms such as the regulation of the mTEC differentiation program. Controls the medullary accumulation of thymic dendritic cells and the development of regulatory T-cell through the regulation of XCL1 expression. Regulates the production of CCR4 and CCR7 ligands in medullary thymic epithelial cells and alters the coordinated maturation and migration of thymocytes. In thimic B-cells, allows the presentation of licensing-dependent endogenous self-anitgen for negative selection. In secondary lymphoid organs, induces functional inactivation of CD4(+) T-cells. Expressed by a distinct bone marrow-derived population, induces self-tolerance through a mechanism that does not require regulatory T-cells and is resitant to innate inflammatory stimuli (By similarity).
Entrez Zusammenfassung
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED).
Gewebespezifität
Widely expressed. Expressed at higher level in thymus (medullary epithelial cells and monocyte-dendritic cells), pancreas, adrenal cortex and testis. Expressed at lower level in the spleen, fetal liver and lymph nodes. In secondary lymphoid organs, expressed in a discrete population of bone marrow-derived toleregenic antigen presenting cells (APCs) called extrathymic AIRE expressing cells (eTAC)(at protein level) (PubMed:23993652). Isoform 2 and isoform 3 seem to be less frequently expressed than isoform 1, if at all.
Rolle bei Krankheiten
Autoimmune polyendocrine syndrome 1, with or without reversible metaphyseal dysplasia: A rare disease characterized by the combination of chronic mucocutaneous candidiasis, hypoparathyroidism and Addison disease. Symptoms of mucocutaneous candidiasis manifest first, followed by hypotension or fatigue occurring as a result of Addison disease. APS1 is associated with other autoimmune disorders including diabetes mellitus, vitiligo, alopecia, hepatitis, pernicious anemia and primary hypothyroidism.
Posttranslationale Modifikation
Phosphorylated. Phosphorylation could trigger oligomerization.
Zellort
Nucleus. Cytoplasm.

Predominantly nuclear but also cytoplasmic (PubMed:11274163, PubMed:14974083). Found in nuclear body-like structures (dots) and in a filamentous vimentin-like pattern (PubMed:11274163, PubMed:14974083, PubMed:26084028). Associated with tubular structures (PubMed:11274163, PubMed:14974083).
Western Blot - Anti-AIRE Antibody (A82607) - Antibodies.com
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Western Blot - Anti-AIRE Antibody (A13643) - Antibodies.com
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Western Blot - Anti-AIRE Antibody (C10123) - Antibodies.com
(3)
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Western Blot - Anti-AIRE Antibody (A84291) - Antibodies.com
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Immunohistochemistry - Anti-AIRE Antibody (A83252) - Antibodies.com
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Western Blot - Anti-AIRE (phospho Ser156) Antibody (A8286) - Antibodies.com
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Western Blot - Anti-AIRE Antibody (B8286) - Antibodies.com
Produkt anzeigen10µg Versuchsgrößen
Western blot - AIRE Antibody from Signalway Antibody (32424) - Antibodies.com
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Anti-AIRE Antibody from Bioworld Technology (BS6860) - Antibodies.com
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Anti-AIRE (P126) Antibody from Bioworld Technology (BS1879) - Antibodies.com
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Western blot - AIRE-1 Polyclonal Antibody from Signalway Antibody (40562) - Antibodies.com
Western blot - AIRE Antibody from Signalway Antibody (33590) - Antibodies.com
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Western Blot - Anti-Aire Antibody (BPA1005) - Antibodies.com
Western blot - AIRE (Phospho-Ser156) Antibody from Signalway Antibody (11782) - Antibodies.com

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