alpha Defensin 1 ist ein Gen, das durch das Symbol DEFA1 kodiert wird. Andere Namen sind: Neutrophil defensin 1; Defensin, alpha 1; HNP-1; HP-1; DEFA1; DEF1; DEFA2; MRS. alpha Defensin 1 hat eine Masse von 10.2kDa und eine Aminosäurelänge von 94.
Wir bieten 6 antikörper gegen alpha Defensin 1, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Defensin 1 and defensin 2 have antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane.
Entrez Zusammenfassung
Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. The protein encoded by this gene, defensin, alpha 1, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 3 by only one amino acid. This gene and the gene encoding defensin, alpha 3 are both subject to copy number variation.
Sequenzähnlichkeiten
Belongs to the alpha-defensin family.
Posttranslationale Modifikation
ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production.
