Angiotensin II Type 1 Receptor ist ein Gen, das durch das Symbol AGTR1 kodiert wird. Andere Namen sind: Type-1 angiotensin II receptor; AT1AR; AT1BR; Angiotensin II type-1 receptor; AT1; AGTR1; AGTR1A; AGTR1B; AT2R1; AT2R1B. Angiotensin II Type 1 Receptor hat eine Masse von 41.06kDa, eine Aminosäurelänge von 359, und ist an Renal tubular dysgenesis beteiligt.
Wir bieten 7 antikörper gegen Angiotensin II Type 1 Receptor, aufgewachsen in Kaninchen und Ziege, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Entrez Zusammenfassung
Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene.
Gewebespezifität
Liver, lung, adrenal and adrenocortical adenomas.
Rolle bei Krankheiten
Renal tubular dysgenesis: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype).
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family.
Posttranslationale Modifikation
C-terminal Ser or Thr residues may be phosphorylated.
