ARHGEF7 ist ein Gen, das durch das Symbol ARHGEF7 kodiert wird. Andere Namen sind: Rho guanine nucleotide exchange factor 7; Beta-Pix; COOL-1; PAK-interacting exchange factor beta; p85; COOL1; KIAA0142; P85SPR; PAK3BP; PIXB. ARHGEF7 hat eine Masse von 90.01kDa und eine Aminosäurelänge von 803.
Wir bieten 10 antikörper gegen ARHGEF7, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA, ICC/IF and IP mit Proben abgeleitet von Human, Maus, Ratte und Affe.
Gen- und Proteininformationen
UniProt Zusammenfassung
Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Entrez Zusammenfassung
This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene.
Posttranslationale Modifikation
Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1.
Zellort
Cell junction > Focal adhesion. Cell projection > Ruffle. Cytoplasm > Cell cortex. Cell projection > Lamellipodium.
Detected at cell adhesions. A small proportion is detected at focal adhesions.
