BAFF Receptor ist ein Gen, das durch das Symbol TNFRSF13C kodiert wird. Andere Namen sind: Tumor necrosis factor receptor superfamily member 13C; B-cell-activating factor receptor; BAFF-R; BLyS receptor 3; TNFRSF13C; BAFFR; BR3. BAFF Receptor hat eine Masse von 18.86kDa, eine Aminosäurelänge von 184, und ist an Immunodeficiency, common variable, 4 beteiligt.
Wir bieten 18 antikörper gegen BAFF Receptor, aufgewachsen in Kaninchen, Maus und Human, welche geeignet sind für WB, IHC, ELISA and FC mit Proben abgeleitet von Human, Maus, Ratte und Huhn.
Gen- und Proteininformationen
UniProt Zusammenfassung
B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Entrez Zusammenfassung
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival.
Gewebespezifität
Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
Rolle bei Krankheiten
Immunodeficiency, common variable, 4: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low.
