Bmi1 ist ein Gen, das durch das Symbol BMI1 kodiert wird. Andere Namen sind: Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; RING finger protein 51; PCGF4; RNF51. Bmi1 hat eine Masse von 36.95kDa und eine Aminosäurelänge von 326.
Wir bieten 21 antikörper gegen Bmi1, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte und Schwein.
Gen- und Proteininformationen
UniProt Zusammenfassung
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:26151332, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:26151332, PubMed:21772249).
Entrez Zusammenfassung
This locus represents naturally occurring read-through transcription between the neighboring COMM domain-containing protein 3 and polycomb complex protein BMI-1 genes on chromosome 10. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product.
Posttranslationale Modifikation
Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation.
Zellort
Nucleus. Cytoplasm.
