C1orf77 ist ein Gen, das durch das Symbol CHTOP kodiert wird. Andere Namen sind: Chromatin target of PRMT1 protein; Friend of PRMT1 protein; Small arginine- and glycine-rich protein; SRAG; CHTOP; FOP. C1orf77 hat eine Masse von 26.4kDa und eine Aminosäurelänge von 248.
Wir bieten 2 antikörper gegen C1orf77, aufgewachsen in Ratte, welche geeignet sind für WB, IHC, ICC/IF and IP mit Proben abgeleitet von Maus.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789).
Entrez Zusammenfassung
This gene encodes a small nuclear protein that is characterized by an arginine and glycine rich region. This protein may have an important role in the regulation of fetal globin gene expression and in the activation of estrogen-responsive genes. A recent study reported that this protein binds 5-hydroxymethylcytosine (5hmC) and associates with an arginine methyltransferase complex (methylosome), which promotes methylation of arginine 3 of histone H4 (H4R3) and activation of genes involved in glioblastomagenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gewebespezifität
Expressed in an erythroid progenitor cell line derived from peripheral blood. Expressed in glioblastoma cells (PubMed:25284789).
Posttranslationale Modifikation
Asymmetrically methylated by PRMT1 (PubMed:25284789). Symmetrically methylated by PRMT5 (By similarity).
Zellort
Nucleus. Nucleus > Nucleolus. Nucleus > Nucleoplasm. Nucleus speckle.
Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332).
