C5R1 ist ein Gen, das durch das Symbol C5AR1 kodiert wird. Andere Namen sind: C5a anaphylatoxin chemotactic receptor 1; C5a anaphylatoxin chemotactic receptor; C5a-R; C5AR1; C5AR. C5R1 hat eine Masse von 39.34kDa und eine Aminosäurelänge von 350.
Wir bieten 25 antikörper gegen C5R1, aufgewachsen in Kaninchen, Maus, Ziege und Ratte, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte, Rind, Kaninchen und Frettchen.
Gen- und Proteininformationen
UniProt Zusammenfassung
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).
Sequenzähnlichkeiten
Belongs to the G-protein coupled receptor 1 family.
Posttranslationale Modifikation
Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist (PubMed:11342590). Sulfation at Tyr-14 is important for CHIPS binding (PubMed:21706042).
Zellort
Cell membrane. Cytoplasmic vesicle.
Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles.
