Carbonic Anhydrase IX ist ein Gen, das durch das Symbol CA9 kodiert wird. Andere Namen sind: Carbonic anhydrase 9; Carbonate dehydratase IX; CA-IX; Membrane antigen MN; P54/58N; Renal cell carcinoma-associated antigen G250; RCC-associated antigen G250; pMW1; CA9; G250; MN. Carbonic Anhydrase IX hat eine Masse von 49.7kDa und eine Aminosäurelänge von 459.
Wir bieten 22 antikörper gegen Carbonic Anhydrase IX, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human und Pferd.
Gen- und Proteininformationen
UniProt Zusammenfassung
Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.
Entrez Zusammenfassung
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.
Gewebespezifität
Expressed primarily in carcinoma cells lines. Expression is restricted to very few normal tissues and the most abundant expression is found in the epithelial cells of gastric mucosa.
Sequenzähnlichkeiten
Belongs to the alpha-carbonic anhydrase family.
Posttranslationale Modifikation
Asn-346 bears high-mannose type glycan structures.
Zellort
Nucleus. Nucleus > Nucleolus. Cell membrane. Cell projection > Microvillus membrane.
Found on the surface microvilli and in the nucleus, particularly in nucleolus.
