Catalase ist ein Gen, das durch das Symbol CAT kodiert wird. Es ist auch bekannt als CAT. Catalase hat eine Masse von 59.76kDa, eine Aminosäurelänge von 527, und ist an Acatalasemia beteiligt.
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Gen- und Proteininformationen
UniProt Zusammenfassung
Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
Entrez Zusammenfassung
This gene encodes catalase, a key antioxidant enzyme in the bodies defense against oxidative stress. Catalase is a heme enzyme that is present in the peroxisome of nearly all aerobic cells. Catalase converts the reactive oxygen species hydrogen peroxide to water and oxygen and thereby mitigates the toxic effects of hydrogen peroxide. Oxidative stress is hypothesized to play a role in the development of many chronic or late-onset diseases such as diabetes, asthma, Alzheimer's disease, systemic lupus erythematosus, rheumatoid arthritis, and cancers. Polymorphisms in this gene have been associated with decreases in catalase activity but, to date, acatalasemia is the only disease known to be caused by this gene.
Rolle bei Krankheiten
Acatalasemia: A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait.
Sequenzähnlichkeiten
Belongs to the catalase family.
Posttranslationale Modifikation
The N-terminus is blocked.
