CD1a ist ein Gen, das durch das Symbol CD1A kodiert wird. Andere Namen sind: T-cell surface glycoprotein T-cell surface antigen T6/Leu-6; hTa1 thymocyte antigen. CD1a hat eine Masse von 37.08kDa und eine Aminosäurelänge von 327.
Wir bieten 42 antikörper gegen CD1a, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF and FC mit Proben abgeleitet von Human, Maus und Hund.
Gen- und Proteininformationen
UniProt Zusammenfassung
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Entrez Zusammenfassung
This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to the plasma membrane and to recycling vesicles of the early endocytic system. Alternative splicing results in multiple transcript variants.
Gewebespezifität
Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.
Zellort
Cell membrane. Membrane raft. Endosome membrane.
Subject to intracellular trafficking between the cell membrane and endosomes (PubMed:11231314). Localizes to cell surface lipid rafts (PubMed:18178838).
