CD300 antigen ist ein Gen, das durch das Symbol CD300A kodiert wird. Andere Namen sind: CMRF35-like molecule 8; CLM-8-like family member A; CMRF-35-H9; CMRF35-H9; CMRF35-H; IRC1/IRC2; Immunoglobulin superfamily member 12; IgSF12; Inhibitory receptor protein 60; IRp60; NK inhibitory receptor; CD300A; CMRF35H; IGSF12. CD300 antigen hat eine Masse von 33.2kDa und eine Aminosäurelänge von 299.
Wir bieten 8 antikörper gegen CD300 antigen, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB and FC mit Proben abgeleitet von Human.
Gen- und Proteininformationen
UniProt Zusammenfassung
Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923).
Entrez Zusammenfassung
This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed not only by natural killer (NK) cells but also by T-cell subsets, B-cells, dendritic cells, mast cells, granulocytes and monocytes.
Sequenzähnlichkeiten
Belongs to the CD300 family.
Posttranslationale Modifikation
Phosphorylated on tyrosine.
