CD89 ist ein Gen, das durch das Symbol FCAR kodiert wird. Andere Namen sind: Immunoglobulin alpha Fc receptor; IgA Fc receptor; FCAR. CD89 hat eine Masse von 32.27kDa und eine Aminosäurelänge von 287.
Wir bieten 13 antikörper gegen CD89, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus und Primaten.
Gen- und Proteininformationen
UniProt Zusammenfassung
Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
Entrez Zusammenfassung
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gewebespezifität
Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces.
