Ceruloplasmin ist ein Gen, das durch das Symbol CP kodiert wird. Andere Namen sind: Ferroxidase; CP. Ceruloplasmin hat eine Masse von 122.21kDa, eine Aminosäurelänge von 1065, und ist an Aceruloplasminemia beteiligt.
Wir bieten 10 antikörper gegen Ceruloplasmin, aufgewachsen in Kaninchen, Ziege und Sheep, welche geeignet sind für WB, IHC, ELISA, ICC/IF, IP and Dot mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. May also play a role in fetal lung development or pulmonary antioxidant defense (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe(II)transferrin to Fe(III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.
Gewebespezifität
Expressed by the liver and secreted in plasma.
Rolle bei Krankheiten
Aceruloplasminemia: An autosomal recessive disorder of iron metabolism characterized by iron accumulation in the brain as well as visceral organs. Clinical features consist of the triad of retinal degeneration, diabetes mellitus and neurological disturbances.
Sequenzähnlichkeiten
Belongs to the multicopper oxidase family.
Zellort
Secreted.
Colocalizes with GCP1 in secretory intracellular compartments.
