Claudin 7 ist ein Gen, das durch das Symbol CLDN7 kodiert wird. Andere Namen sind: Claudin-7; CLDN-7; CLDN7; CEPTRL2; CPETRL2. Claudin 7 hat eine Masse von 22.42kDa und eine Aminosäurelänge von 211.
Wir bieten 12 antikörper gegen Claudin 7, aufgewachsen in Kaninchen und Maus, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
Plays a major role in tight junction-specific obliteration of the intercellular space.
Entrez Zusammenfassung
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Differential expression of this gene has been observed in different types of malignancies, including breast cancer, ovarian cancer, hepatocellular carcinomas, urinary tumors, prostate cancer, lung cancer, head and neck cancers, thyroid carcinomas, etc.. Alternatively spliced transcript variants encoding different isoforms have been found.
Gewebespezifität
Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Sequenzähnlichkeiten
Belongs to the claudin family.
Posttranslationale Modifikation
Phosphorylated.
Zellort
Cell membrane. Basolateral cell membrane. Cell junction > Tight junction.
Co-localizes with EPCAM at the basolateral cell membrane and tight junction.
