+1 (314) 370-6046 oderKontakt

Anti-Cyclin D1 Antikörper

Showing 1- of 70 Products

Cyclin D1 ist ein Gen, das durch das Symbol CCND1 kodiert wird. Andere Namen sind: G1/S-specific cyclin-D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene; CCND1; BCL1; PRAD1. Cyclin D1 hat eine Masse von 33.73kDa, eine Aminosäurelänge von 295, und ist an Multiple myeloma beteiligt.

Wir bieten 70 antikörper gegen Cyclin D1, aufgewachsen in Kaninchen, Maus und Ziege, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte, Affe, Hund, Primaten und Zebrafisch.

Gen- und Proteininformationen

UniProt Zusammenfassung
Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Entrez Zusammenfassung
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
Rolle bei Krankheiten
Multiple myeloma: A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.
Sequenzähnlichkeiten
Belongs to the cyclin family. Cyclin D subfamily.
Posttranslationale Modifikation
Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.
Zellort
Nucleus. Cytoplasm. Nucleus membrane.

Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.
Anti-Cyclin D1 (L283) Antibody from Bioworld Technology (BS1741) - Antibodies.com
(2)
Western Blot - Anti-Cyclin D1 Antibody [ARC0300] (A306339) - Antibodies.com
(10)
Produkt anzeigenKnockout-validierter
Immunohistochemistry - Anti-Cyclin D1 Antibody [DCS-6] (A249856) - Antibodies.com
(4)
Immunohistochemistry - Anti-Cyclin D1 Antibody [DCS-6] - BSA and Azide free (A253036) - Antibodies.com
(4)
Western Blot - Anti-Cyclin D1 Antibody (A80774) - Antibodies.com
(4)
Western Blot - Anti-Cyclin D1 (phospho Thr286) Antibody (A0417) - Antibodies.com
(3)
Produkt anzeigen10µg Versuchsgrößen
Flow Cytometry - Anti-Cyclin D1 Antibody [DCS-6] (A86869) - Antibodies.com
Produkt anzeigen10µg Versuchsgrößen
Immunohistochemistry - Anti-Cyclin D1 Antibody [SPM587] - BSA and Azide free (A253036) - Antibodies.com
(2)
Immunohistochemistry - Anti-Cyclin D1 Antibody [SPM587] (A249856) - Antibodies.com
(2)
Antibodies.com Image Placeholder - Entdecken Sie mehr für weniger
Produkt anzeigen10µg Versuchsgrößen
Antibodies.com Image Placeholder - Entdecken Sie mehr für weniger
Western Blot - Anti-Cyclin D1 (phospho Thr286) Antibody (A305286) - Antibodies.com
(4)
Flow Cytometry - Anti-Cyclin D1 Antibody [DCS-6] (PE) (A86871) - Antibodies.com
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/809] (A249858) - Antibodies.com
(5)
Antibodies.com Image Placeholder - Entdecken Sie mehr für weniger
Produkt anzeigen10µg Versuchsgrößen
Immunohistochemistry - Anti-Cyclin D1 Antibody (B0417) - Antibodies.com
(2)
Produkt anzeigen10µg Versuchsgrößen
Flow Cytometry - Anti-Cyclin D1 Antibody [SPM587] (PE) (A251189) - Antibodies.com
(2)
Flow Cytometry - Anti-Cyclin D1 Antibody [DCS-6] (PE) (A251147) - Antibodies.com
(2)
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/809] - BSA and Azide free (A253038) - Antibodies.com
(5)
Immunohistochemistry - Anti-Cyclin D1 Antibody [RM241] (A121455) - Antibodies.com
(4)
Produkt anzeigenRekombinant Antikörper
Western Blot - Anti-Cyclin D1 Antibody (A80795) - Antibodies.com
Western Blot - Anti-Cyclin D1 Antibody (B0879) - Antibodies.com
Produkt anzeigen10µg Versuchsgrößen
Western Blot - Anti-Cyclin D1 Antibody (A305166) - Antibodies.com
(2)
Western Blot - Anti-Cyclin D1 Antibody (R12-2666) - Antibodies.com
Produkt anzeigen10µg Versuchsgrößen
Immunohistochemistry - Anti-Cyclin D1 Antibody - Antibodies.com (A8209)
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/2593] (A249859) - Antibodies.com
(3)
Produkt anzeigenMonospezifischer Antikörper
Western Blot - Anti-Cyclin D1 Antibody (A11552) - Antibodies.com
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/2593] - BSA and Azide free (A253039) - Antibodies.com
(3)
Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/3370R] - BSA and Azide free (A253041) - Antibodies.com
(3)
Immunohistochemistry - Anti-Cyclin D1 Antibody [CCND1/3370R] (A249861) - Antibodies.com
(3)
Immunohistochemistry - Anti-Cyclin D1 Antibody [rCCND1/4752] - BSA and Azide free (A253034) - Antibodies.com
(2)
Produkt anzeigenRekombinant Antikörper
SDS-PAGE - Anti-Cyclin D1 Antibody [CCND1/3548] - BSA and Azide free (A253040) - Antibodies.com
(2)
Produkt anzeigenMonospezifischer Antikörper
Immunohistochemistry - Anti-Cyclin D1 Antibody [rCCND1/4752] (A249854) - Antibodies.com
(2)
Produkt anzeigenRekombinant Antikörper
Antibodies.com Image Placeholder - Entdecken Sie mehr für weniger
SDS-PAGE - Anti-Cyclin D1 Antibody [CCND1/3548] (A249860) - Antibodies.com
(2)
Produkt anzeigenMonospezifischer Antikörper
Antibodies.com Image Placeholder - Entdecken Sie mehr für weniger
Flow Cytometry - Anti-Cyclin D1 Antibody [CCND1/809] (PE) (A251151) - Antibodies.com
Western Blot - Anti-CCND1 Antibody (A85171) - Antibodies.com
Flow Cytometry - Anti-Cyclin D1 Antibody - Antibodies.com (A8306)
Immunohistochemistry - Anti-Cyclin D1 Antibody [IHC452] (A324531) - Antibodies.com
Antibodies.com Image Placeholder - Entdecken Sie mehr für weniger
Antibodies.com Image Placeholder - Entdecken Sie mehr für weniger
Anti-Cyclin D1 Antibody from Bioworld Technology (BS9827M) - Antibodies.com
(7)
Cyclin D1 Antibody from Signalway Antibody (39315) - Antibodies.com
(2)
Western blot - Cyclin D1 Polyclonal Antibody from Signalway Antibody (40803) - Antibodies.com
(2)
Western blot - CCND1 Antibody from Signalway Antibody (32262) - Antibodies.com
(2)
Anti-Cyclin D1 Antibody from FabGennix (CYCD1-101AP) - Antibodies.com
CCND1 Antibody from Signalway Antibody (31064) - Antibodies.com
(2)
Anti-Cyclin D1 Antibody from FabGennix (CYCD1-121AP) - Antibodies.com
Antibodies.com Image Placeholder - Entdecken Sie mehr für weniger

Zeigt 1-50 von 70 Produkten

Suchfilter Hauptmenü Kontakt 0Kasse
Oben