DLK ist ein Gen, das durch das Symbol DLK1 kodiert wird. Andere Namen sind: Protein delta homolog 1-1; pG21. DLK hat eine Masse von 41.3kDa und eine Aminosäurelänge von 383.
Wir bieten 9 antikörper gegen DLK, aufgewachsen in Kaninchen und Human, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May have a role in neuroendocrine differentiation.
Entrez Zusammenfassung
This gene encodes a transmembrane protein that contains multiple epidermal growth factor repeats that functions as a regulator of cell growth. The encoded protein is involved in the differentiation of several cell types including adipocytes. This gene is located in a region of chromosome 14 frequently showing unparental disomy, and is imprinted and expressed from the paternal allele. A single nucleotide variant in this gene is associated with child and adolescent obesity and shows polar overdominance, where heterozygotes carrying an active paternal allele express the phenotype, while mutant homozygotes are normal.
Gewebespezifität
Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue.
Posttranslationale Modifikation
N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Zellort
Membrane. Cytoplasm.
