DOK1 ist ein Gen, das durch das Symbol DOK1 kodiert wird. Andere Namen sind: Docking protein 1; Downstream of tyrosine kinase 1; p62(dok); pp62. DOK1 hat eine Masse von 52.39kDa und eine Aminosäurelänge von 481.
Wir bieten 12 antikörper gegen DOK1, aufgewachsen in Kaninchen, welche geeignet sind für WB, IHC, ELISA and ICC/IF mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.
Entrez Zusammenfassung
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene.
Gewebespezifität
Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. Expressed in breast cancer.
Sequenzähnlichkeiten
Belongs to the DOK family. Type A subfamily.
Posttranslationale Modifikation
Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS.
Zellort
Cytoplasm. Nucleus.
