EB2 ist ein Gen, das durch das Symbol MAPRE2 kodiert wird. Andere Namen sind: Microtubule-associated protein RP/EB family member 2; APC-binding protein End-binding protein 2; MAPRE2; RP1. EB2 hat eine Masse von 37.03kDa, eine Aminosäurelänge von 327, und ist an Skin creases, congenital symmetric circumferential, 2 beteiligt.
Wir bieten 3 antikörper gegen EB2, aufgewachsen in Kaninchen und Ratte, welche geeignet sind für WB, ICC/IF and IP mit Proben abgeleitet von Human, Maus und Ratte.
Gen- und Proteininformationen
UniProt Zusammenfassung
May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration (By similarity).
Entrez Zusammenfassung
The protein encoded by this gene shares significant homology to the adenomatous polyposis coli (APC) protein-binding EB1 gene family. This protein is a microtubule-associated protein that is necessary for spindle symmetry during mitosis. It is thought to play a role in the tumorigenesis of colorectal cancers and the proliferative control of normal cells. Alternative splicing of this gene results in multiple transcript variants.
Gewebespezifität
Expressed in different tumor cell lines. Up-regulated in activated B- and T-lymphocytes.
Rolle bei Krankheiten
Skin creases, congenital symmetric circumferential, 2: An autosomal dominant disease characterized by multiple, symmetric, circumferential rings of folded skin, affecting primarily the limbs. Affected individuals also exhibit intellectual disability, cleft palate, and dysmorphic features.
Sequenzähnlichkeiten
Belongs to the MAPRE family.
Zellort
Cytoplasm > Cytoskeleton.
Associated with the microtubule network. Accumulates at the plus end of microtubules.
