EpCAM ist ein Gen, das durch das Symbol EPCAM kodiert wird. Andere Namen sind: Epithelial cell adhesion molecule; Ep-CAM; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1. EpCAM hat eine Masse von 34.93kDa, eine Aminosäurelänge von 314, und ist an folgenden Krankheiten beteiligt: Diarrhea 5, with tufting enteropathy, congenital; Hereditary non-polyposis colorectal cancer 8.
Wir bieten 141 antikörper gegen EpCAM, aufgewachsen in Kaninchen, Maus, Ziege und Ratte, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC, IP and ChIP mit Proben abgeleitet von Human, Maus, Ratte, Hund und Katze.
Gen- und Proteininformationen
UniProt Zusammenfassung
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Entrez Zusammenfassung
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
Gewebespezifität
Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
Rolle bei Krankheiten
Diarrhea 5, with tufting enteropathy, congenital: An intractable diarrhea of infancy characterized by villous atrophy and absence of inflammation, with intestinal epithelial cell dysplasia manifesting as focal epithelial tufts in the duodenum and jejunum.
Hereditary non-polyposis colorectal cancer 8: An autosomal dominant disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early-onset colorectal carcinoma (CRC) and extra-colonic tumors of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the Western world. Clinically, HNPCC is often divided into two subgroups. Type I is characterized by hereditary predisposition to colorectal cancer, a young age of onset, and carcinoma observed in the proximal colon. Type II is characterized by increased risk for cancers in certain tissues such as the uterus, ovary, breast, stomach, small intestine, skin, and larynx in addition to the colon. Diagnosis of classical HNPCC is based on the Amsterdam criteria: 3 or more relatives affected by colorectal cancer, one a first degree relative of the other two; 2 or more generation affected; 1 or more colorectal cancers presenting before 50 years of age; exclusion of hereditary polyposis syndromes. The term 'suspected HNPCC' or 'incomplete HNPCC' can be used to describe families who do not or only partially fulfill the Amsterdam criteria, but in whom a genetic basis for colon cancer is strongly suspected.
Sequenzähnlichkeiten
Belongs to the EPCAM family.
Posttranslationale Modifikation
Hyperglycosylated in carcinoma tissue as compared with autologous normal epithelia. Glycosylation at Asn-198 is crucial for protein stability.
Zellort
Lateral cell membrane. Cell junction > Tight junction.
Colocalizes with CLDN7 at the lateral cell membrane and tight junction.
