FCRL2 ist ein Gen, das durch das Symbol FCRL2 kodiert wird. Andere Namen sind: Fc receptor-like protein 2; FcR-like protein 2; Fc receptor homolog 2; FcRH2; IFGP family protein 4; Immunoglobulin receptor translocation-associated protein 4; SH2 domain-containing phosphatase anchor protein 1; FCRH2; IFGP4; IRTA4; SPAP1. FCRL2 hat eine Masse von 55.54kDa und eine Aminosäurelänge von 508.
Wir bieten 2 antikörper gegen FCRL2, aufgewachsen in Maus und Ziege, welche geeignet sind für WB, ELISA and FC mit Proben abgeleitet von Human.
Gen- und Proteininformationen
UniProt Zusammenfassung
May have an regulatory role in normal and neoplastic B cell development.
Entrez Zusammenfassung
This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains one immunoreceptor-tyrosine activation motif and two immunoreceptor-tyrosine inhibitory motifs. This protein may be a prognostic marker for chronic lymphocytic leukemia. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Gewebespezifität
Expressed in the secondary lymphoid organs, spleen and lymph node. Expression is limited to the mature B-cell lines. Highly expressed in CD19 and within the mantle zones of the tonsil tissue. Isoform 2 is expressed in the spleen, peripheral blood and bone marrow. Isoform 2 and isoform 4 are expressed in B-cell lines. Preferentially expressed in memory B-cells (at protein level).
Posttranslationale Modifikation
Isoform 2 is N- and O-glycosylated, and phosphorylated.
