Fibrillarin ist ein Gen, das durch das Symbol FBL kodiert wird. Andere Namen sind: rRNA 2'-O-methyltransferase 34 kDa nucleolar scleroderma antigen; Histone-glutamine methyltransferase; FBL; FIB1; FLRN. Fibrillarin hat eine Masse von 33.78kDa und eine Aminosäurelänge von 321.
Wir bieten 11 antikörper gegen Fibrillarin, aufgewachsen in Kaninchen, Maus, Ziege und Huhn, welche geeignet sind für WB, IHC, ELISA, ICC/IF, FC and IP mit Proben abgeleitet von Human, Maus, Ratte, Affe, C. elegans, Hund, Drosophila, Pferd, S. cerevisiae und Zebrafisch.
Gen- und Proteininformationen
UniProt Zusammenfassung
S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins (PubMed:24352239, PubMed:30540930). Involved in pre-rRNA processing by catalyzing the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA (PubMed:30540930). Site specificity is provided by a guide RNA that base pairs with the substrate (By similarity). Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity). Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ104me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (PubMed:24352239, PubMed:30540930).
Entrez Zusammenfassung
This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
Sequenzähnlichkeiten
Belongs to the methyltransferase superfamily. Fibrillarin family.
Posttranslationale Modifikation
Ubiquitinated. Ubiquitination leads to proteasomal degradation (PubMed:19208757). Deubiquitinated by USP36 (PubMed:19208757).
Zellort
Nucleus > Nucleolus.
Fibrillar region of the nucleolus.
